Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...
Genomic instability arises when the faithful duplication and transmission of DNA is compromised, leading to mutations, chromosomal rearrangements and copy number variations with broad implications for ...
During the early phases of oncogenic clonal expansion, precancerous cells experience replication stress that threatens both genomic integrity and viability. How replication stress tolerance (RST) ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results