Leptin is a peptide hormone secreted primarily by adipocytes that informs the central nervous system about energy stores and regulates appetite and metabolism. In rare cases, pathogenic variants in ...

The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic ...

The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) recommended marketing authorization for metreleptin (Myalepta, Aegerion Pharmaceuticals BV) for the treatment of ...

Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...

San Antonio, Texas (June 19, 2019) - The global obesity epidemic is so far-reaching it now has an overarching name: globesity. Texas Biomed Staff Scientist Raul Bastarrachea, M.D., is part of a team ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic ...

Please provide your email address to receive an email when new articles are posted on . Increasing leptin levels are independently associated with decreasing testosterone and could be a cause for ...

Scientists discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of body ...