Architectural integrity of the mitotic spindle is required for efficient chromosome congression and accurate chromosome segregation to ensure mitotic fidelity. Tumour suppressor PTEN has multiple ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

The mechanical process of cell division exerts powerful, if microscopic, forces. How do the molecular machines that power it ...

When a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells. Although this is known to be extremely complicated and ...

Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary Gergely, Eileen O’Toole, Ammon Crapo, Loren Hough, J. Richard McIntosh ...

Mobile spindles previously unknown in plants To solve this puzzle, the team delved into the molecular biology box of tricks: they modified spreading earthmoss (Physcomitrella) plants, removing five ...

When cells divide, microtubules—a dynamic network of protein filaments—form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and animals ...

Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...

A research team led by Prof. YAO Xuebiao, LIU Xing and ZANG Jianye from University of Science and Technology of China (USTC) revealed how crotonylation of EB1 helped orientate spindle in mitosis. The ...

Every biology class learns about mitosis, which involves copying each of a cell's DNA-containing chromosomes, then separating them into two newly created cells. The act of chromosome separation is ...

Normal spindles have two ends, known as spindle poles. Weaver and her colleagues found that paclitaxel and other microtubule poisons cause abnormalities that lead cells to form three, four or ...