Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new ...

Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core prognostic genes that shape tumor stemness and a ...

Recently, the research team led by Wei Li and Chao Liu from Guangzhou Medical University Affiliated Women and Children's Medical Center, in collaboration with Fei Gao’s team from the Institute of ...

A new feature of the genetic mutation responsible for the progressive neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome -- the formation of 'R-loops,' has been discovered.