This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core prognostic genes that shape tumor stemness and a ...

There are many ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops. These ...

A new study led by researchers at The University of Texas MD Anderson Cancer Center has uncovered a previously unknown connection between nucleic acid structures called R-loops and age-related ...

This study is achieved by Professor Wei Xu’s research team from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences. The research team established mDRIP-seq, a ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...