Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Illustration of fork-MMEJ and BIR pathways in repairing single-ended DNA double-stranded breaks at broken replication forks, highlighting ATR-mediated regulation of the transition between these two ...