Drug resistance is defined as the lack of expected response to a standard therapeutic dose of a drug or as resistance resulting from biologic changes in the target, as occurs in antibiotic resistance.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Overview: Heparin is a blood thinner that is used to prevent or treat blood clots. It may be injected under the skin or into a blood vessel. The most common side effects are irritation at the ...