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Decoding your IGAN lab results: Understanding EGFR and UPCR, and predicting future kidney health

For many people with IgA nephropathy (IgAN), a condition in which immunoglobulin A (IgA) antibodies accumulate in the kidneys and trigger inflammation, kidney function stays stable for many years. For ...
European Medical Journal

eGFR Slope Predicts Kidney Outcomes in IgA Nephropathy

GFR slope predicts kidney outcomes in IgA nephropathy beyond static measures. Learn how this could refine trials and risk ...
MPR

FDA to Review Zipalertinib for Metastatic EGFR Ex20ins NSCLC

Acceptance of the New Drug Application is based on findings from a phase 2b portion of the open-label REZILIENT1 clinical trial.
Zacks Investment Research on MSN

BDTX: What silevertinib data say about EGFR NSCLC upside

Black Diamond Therapeutics, Inc. BDTX is building its equity story around a single, high-leverage asset: silevertinib, a brain-penetrant, fourth-generation epidermal growth factor receptor (EGFR) ...

BDTX and the CNS-Active EGFR Trend: Why C797S Is the Prize

Black Diamond Therapeutics bets on brain-penetrant EGFR drug silevertinib, targeting C797S resistance and CNS metastases as key edge in crowded lung cancer market.
The American Journal of Managed Care

CNS Metastases in EGFR-Mutant NSCLC: Emerging Therapeutic Strategies and Ongoing Challenges

CNS metastases in EGFR-mutant NSCLC are prevalent and worsen prognosis, especially with acquired progression during treatment. Amivantamab plus lazertinib shows promising CNS activity, but current ...
Healio

Longer time with low eGFR ups odds for preemptive, living donor transplant in pediatric CKD

Pediatric patients who lived with a low eGFR longer without dialysis had better odds to receive a preemptive or living donor ...